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c A consultant snapshot of MD simulation. LTB coloured in white is the initial pose from the cryo-EM construction, LTB coloured in eco-friendly will be the agent pose on the MD simulation. Lessen panel, RMSD with the LTB4 trajectories while in the simulations. d A SRE reporter assay of important mutants while in the ligand-binding pocket. LTB4, 300